Hydroxyurea has also caused nail sloughing. Absolute or true polycythemia is characterized by an expanded red blood cell mass. Secondary polycythemia refers to a group of diseases triggered by an exaggerated erythropoietin dependent stimulation of red cell production. Released in November 2003, Jak II is the acclaimed sequel to Jak and Daxter. Because of the obvious signs of dehydration, relative polycythemia is usually easily recognized and simply corrected with aggressive fluid therapy. He was the operator of the power station in Haven City, and a close ally of the Underground movement, described as one of their best informants. Techno Babble: Vin spouts a ton of this when Jak doubts his ability to activate the palace's old elevator system. Would you like to change your VIN email? Vin voiced by Robert Patrick Benedict and 2 others . 2 Jewova Dye chwazi kèk moun pou vin zanmi l. Pa egzanp, Abraram se te youn nan zanmi Jewova te genyen (Ezayi 41:8; Jak 2:23). He possesses an Econecic Energy Doctorate, for which he wrote on Precurian theoretical physics.[5]. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Because of an underappreciation of the normal upper limit of the PCV in cats (48%) versus dogs (56%), polycythemia is generally underdiagnosed in cats. The blood volume and red cell mass could be determined by labeling red cells radioactively or with biotin. Long-term control of absolute polycythemia may be achieved by periodic phlebotomies, radioactive phosphorus, and/or chemotherapy. New insight into the causes of primary and secondary polycythemias has been gained in human and veterinary medicine. If possible, renal and other tumors/masses should be removed or treated and cardiopulmonary distress should be corrected. Clinical signs of absolute polycythemia are characterized by manifestations of the underlying disease process and are associated with hyperviscosity and the expanded blood volume. Average score of 5 user reviews. More research is needed in small animals to determine, if such processes are occurring in these polycythemic patients who do not clearly have P. vera. Hence, polycythemia would be more appropriately called erythrocytosis and clinically refers to an increase to an above normal red blood cell count, hematocrit or packed cell volume (PCV), and hemoglobin (Hb) concentration. Polycythemic animals may remain asymptomatic for weeks to years and, in some cases, can be successfully managed for years. However, a bone marrow aspirate for cytologic examination adds no new information, since it fails to differentiate between primary and secondary polycythemias: the myeloproliferative disease resulting in P. vera has no characteristic cytologic or pathologic features of malignancy. Inappropriate secondary polycythemia of renal origin may also be rarely caused by amyloidosis, polycystic kidney disease, glomerulonephritis, and renal fibrosarcoma and lymphoma. Dark blood may be exposed to air to determine if it is deoxyhemoglobin or methemoglobin. Primary polycythemia appears erythropoietin independent and has often been considered synonymous with P. vera in small animals, although additional forms of primary polycythemia need to be considered. Rescue Vin at Strip Mine (**) ----- This is the first time you can choose which mission you take. There are no cytologically characteristic features of the bone marrow cells in P. vera as hematopoietic cells appear to fully mature. Various renal tumors, including nephroblastomas and carcinomas, may result in renal hypoxia and thereby cause elevations in serum erythropoietin and, consequently, inappropriate secondary polycythemia; whereas erythropoietin-producing tumors in other tissues have rarely been documented. The hematocrit is generally only mildly increased, therefore relative polycythemia is rarely associated with signs of hyperviscosity, and the clinical features of the underlying disorder prevail. "I didn't need saving, Torn." During Jak 3, Jak is sent on a mission to find the cipher glyph at the power station. In emergency situations, patients with relative polycythemia will respond to fluid therapy, whereas patients with absolute polycythemia may need to be treated by phlebotomy. He has a constant fear of Metal Heads and is a bit crazy. 1, 2. 5 (4) 4 (0) 3 (1) 2 (0) 1 (0) 4.6 stars. Inappropriate absolute polycythemia includes renal diseases, as well as tumors producing erythropoietin, and is typically associated with typically high serum erythropoietin levels. The rules here are the same as before. While there, the location was attacked by Metal Heads and Vin barricaded himself inside a control room as protection from them. The clinical signs of relative polycythemia are easily recognized and will not be further discussed here. As relative polycythemias are readily recognized, confirmation of a normal blood volume may not be required in clinical practice. He is the founder of the ruling dynasty in Haven City, the House of Mar , with the family crest and Precursor artifact known as the Seal of Mar . Ever since Praxis had been looking for the child as he knew the boy would become the next rightful heir to the throne. During Jak II he served as the opposing factor of Baron Praxis, and, while in disguise as an elderly human, an inside-man working for the Underground resistance movement, charged with watching over the Kid … Vin Art . Vin mentions that he is happier inside his computer system, stating that "those monsters [metal heads] can't get me in here! At some point, he was appointed as foreman for an assignment at the strip mine. The target hematocrit is higher in dogs than in cats, as well as in cases with cardiopulmonary disease, but generally is greater than 50%. Vin, a character in the video games Jak II and Jak 3; Vin, the primary character in the Mistborn series by Brandon Sanderson; Vin Gonzales, a Spider-Man/Marvel Comics supporting character; Vin Petrol, a character in the Corner Shop Show; Places. Cyanosis may only be noted caudally. Animals treated with chemotherapy need to be monitored, not only by PCV measurements as for phlebotomized patients, but also by complete blood cell counts to identify drug induced cytopenias. Jak II 124% complete walkthrough. The other one is behind the first well (if you took my advice above) and can be accessed by taking the path around the Dark Eco lake on the side of Vin's hideout. Jak goes to the Power Room and jump through the Warp Gate to Strip Mine to find and rescue Vin as the Metal Heads attacks. It was one of the first platformers to get rid of the item collection element and focus more on the game's story. The metal heads eventually overran Vin at the power station, and during (what was implied to be) his last few words, Vin sent a transmission to Jak telling him to check the construction site for Kor. There are 2 Eco Wells that are hidden in newly opened areas: One is located behind the building where Vin used to hide before you rescued him. The JAK2 enzyme has been the focus of research lately for treatment for myelofibrosis (MF). Hence, the diagnosis of P. vera is still based on the exclusion of other causes of erythrocytosis. Vin. Furthermore, antithrombotic doses of aspirin (1 mg/kg per day) may be considered, but there is no proof that it reduces the risk of thrombosis, and higher doses may lead to increased bleeding tendencies. Cyanosis or renal size abnormalities may suggest a particular organ failure as well as mechanism, and define the type of the polycythemia. More difficult is the differentiation of absolute polycythemia into primary or secondary polycythemia, which depends on whether the condition is erythropoietin independent or dependent. Granulocyte and platelet counts in the blood would be expected to be increased, but are usually normal. Meeting up at the power station, Vin tells Jak and Daxter that they must destroy the dark eco wells at the strip mine, or else they'll attract more Metal Heads. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of … 3 Si nou leve pou n' salwe nonm ki gen bèl rechanj lan, epi nou di li: Msye, chita la nan bon plas sa a, epi si nou di pòv la: Ou menm, kanpe bò … The author is the director of the non-for-profit PennGen Laboratory which is offering genetic, hematological and blood typing and compatibility testing. Vin worked for the city as the operator of the eco grid and other technology. The bone marrow aspirate is consistent with erythroid hyperplasia, but is not diagnostic for a myeloproliferative disease in humans. "[3] However he also implies that he is lonely, "If you fail, I can always use a companion in here. Phlebotomies can be repeated on a daily basis until the target PCV has been reached. An increased absolute reticulocyte count in light of a polycythemia supports the exaggerated hematopoietic response and documents the presence of an absolute polycythemia. However, secondary cardiac and renal changes due to erythrocytosis may also be observed and confound the interpretation. In cases that require multiple phlebotomies in a short period, replacement of coagulation factors and albumin with plasma may need to be considered. Vin is a very skilled technician and computer operator, stabilizing the eco grid and Shield Wall from the power station, as well as maintaining other Haven City technology. They include hyperemic or cyanotic mucous membranes (due to cardiopulmonary disorders and methemoglobinemia), hemorrhage (epistaxis and hyphema), and neurologic disturbances such as lethargy and seizures. Splenic contraction is an unlikely cause in dogs and cats, as it only marginally increases the PCV. Get daily updates for video game art galleries packed with loads of concept art, character artwork, and promotional pictures. Jak 2 used the groundwork laid by the first game and greatly expanded on it. Animals with methemoglobin reductase deficiency may not need to be treated except during severe stress situations with methylene blue (1 mg/kg IV once). The treatment of relative and absolute polycythemia is clearly different. 30:27. Clinical experience, however, suggests that P. vera may occur rarely compared to other forms of polycythemia. However, his frantic personality dims a little bit when it comes to his work, as he has a sense of pride in his skills and dislikes his expertise being questioned. Chemotherapy with hydroxyurea at 10–25 mg/kg twice daily to once every other day is commonly used. Jak II is a real departure from the formula that was set up in the first Jak and Daxter game. "Every time a second-hand car is bought, it is possible that some of its faults are yet to be discovered; it is a bit like buying a pig in a poke. CU offers 5 ways to follow us so your news feed will never lack new art and inspiration. KIYÈS ou vle kòm zanmi w? ET patients harboring the JAK2 V617F mutation were more likely to develop AVWS than were calreticulin-positive patients (70.3% vs. 45.7%, P=0.02), despite lower platelet counts (median 773 vs. 920×10 9 /L, P=0.05). In fact, animals with a presumptive diagnosis of primary polycythemia as well as cases with an early presentation in life that continues over a chronic course of many years, point strongly to the existence of other forms of primary polycythemia in dogs and cats. LES: Jak is a Fallen Angel and Vin is a scardy cat. Temple of Doom: Mar's Tomb features lots of poisonous spiders, one giant spider, spiked platforms, pools of dark eco and platforms that fall into bottomless pits if … In severely polycythemic patients repeated phlebotomies at no more 20 ml/kg (10 ml in cats) per session with or without simultaneous fluid replacement is the initial approach to lower the PCV to <60%. Vin's most distinctive and impressionable personality trait is his frenetic and paranoid nature. Jak II (Video Game 2003) cast and crew credits, including actors, actresses, directors, writers and more. A single transformed stem cell gains a selective growth advantage and becomes the predominant source of marrow precursors, and the clonality of the bone marrow cells of human patients with P. vera has been documented. This is usually due to a decrease in plasma volume associated with severe dehydration or increased serum total proteins, e.g., profound vomiting and diarrhea, or severe burns. Ashelin said. Hence, the diagnosis of P. vera is still based on the exclusion of other causes of erythrocytosis. Daxter, his ottsel sidekick, saves him and his first thought is revenge against Baron Praxis, the ruler of Haven City. School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphia, PA, USA. During the Metal Head invasion in the latter part of Jak II, Vin alerted Jak that it was Kor who sabotaged the Shield Wall. Vin, California, an unincorporated community in the US; Saint Vincent and the Grenadines (country code) Menu. Jak 2 was a revolutionary game for Naughty Dog. https://jakanddaxter.fandom.com/wiki/Vin?oldid=135647. While Jak was getting artifacts for Onin, Torn was busy also. Jak and Daxter check in with the race team leader at the garage, only to find themselves being unwelcomed again. From that point on, Vin could be seen at the power station operating computers, and would occasionally send Jak on missions at the strip mine and drill platform, two of which involved clearing these locations from metal head eggs. Sometime before the events of Jak II, Baron Praxis, the leader of Haven City, made a deal with Metal Head leader Metal Kor that he would provide them with eco so long as they attack the city only enough to justify his unjust placement in rulership. 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In fact, patients with absolute polycythemia often have an expanded blood volume. 2 Sipoze de moun vin antre nan asanble nou, yonn gen yon bèl rechanj sou li ak yon bag an lò nan dwèt li, lòt la tou pòv ak yon rad chire sou li. However, if the underlying condition cannot be corrected, lowering the PCV into a safe range in patients with absolute polycythemia may be successfully accomplished with repeated phlebotomy and, if needed, chemotherapy. In most cases increased serum erythropoietin concentrations were documented or an association was established based upon the resolution of the polycythemia following the resection of the mass in animals and humans. While channeling Dark Jak, Jak's skin complexion becomes a light gray with a slight purple or blue tint, his hair grows slightly longer, shaggier and spikier, and becomes a darker gray, with his goatee looking somewhat darker, and his eyes grow completely black. The Baron has a daughter, Ashelin, who was born in the Hav… Classically, human patients have serum erythropoietin levels in the low to normal range and erythroid progenitor cells that proliferate and mature independent of erythropoietin, but these culture assays are not robust and readily available. Jak II Art Gallery. We once again follow Jak (and his sidekick Daxter), this time in a new setting. Jak and Daxter Wiki is a FANDOM Games Community. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. He was the operator of the power station in Haven City, and a close ally of the Underground movement, described as one of their best informants.[1]. Oops! - Duration: 30:27. roblesdegracia 91,121 views. In humans with P. vera, Jak-2 mutations have been documented and in a couple of dogs Jak-2 mutations have been found but the test for Jak-2 mutation is not clinically available in veterinary medicine. Chapter XXII: Scardy Vin. Back at Keira's garage, Jak gets a little steamed after Keira talks fondly of Erol and walks away, leaving Daxter to win the class 2 race on his own. This is, however, rarely if ever needed in clinical practice, as dehydration can be readily excluded as cause of relative polycythemia. Ashelin voiced by Susan Eisenberg and 3 others . Yon moun ou renmen. Damas was banished to the Wasteland. Torn said, it wasn't a question. Praxis seized the throne of Haven City by force during the height of the Metal Head Wars by betraying King Damas, who was the rightful monarch of the city as the descendant of Mar, the founder of Haven City. Listen to all the actors who have voiced the following Jak II characters. He was chosen to protect the planet by the Precursors and helped build many relics and structures seen throughout both Jak II and Jak 3, including the Shield Wall and eco grid. One of the newest and most promising treatments for MF is … Polycythemia vera is a myeloproliferative clonal disease that arises from a multipotent hematopoietic progenitor cell in the bone marrow. He also grows large, black claws, and during Ja… Similarly, chronic carbon monoxide intoxication can cause polycythemia with pink mucous membranes. It was also one of the first platformers to add first-person shooting and sandbox gameplay. Urs Giger Bay non kèk nan zanmi Jewova te genyen. Krew's mission is in part (o). Jak. While there, Vin appears. a holographic projection of his mind. Diagnostic tests for absolute polycythemia include a complete blood cell count, absolute reticulocyte count, chemistry screen, urine analysis, blood gases and pulse oxymetry, chest and abdominal radiographs, cardiac examination and an ultrasound to evaluate the kidneys and liver. Tips from the Experts for the Management of... Bacterial Isolation from Urinary Tract Infections, Lower Urinary Tract Disorders in Boxer Dogs, Adverse Effects of Rapid Fluid Administration, Anesthesia & Pain Management for Dentistry, Dental Radiology Techniques & Interpretation, Role of Animal Shelters in Disaster Management. Polydipsia and -uria and splenomegaly has been seen in animals assumed to have P. vera and rarely with other polycythemias. Jak II (known as Jak II: Renegade in Oceania and Europe) is an open world platform third-person shooter action-adventure video game developed by Naughty Dog and published by Sony Computer Entertainment for the PlayStation 2.It is the second game of the Jak and Daxter series and is the sequel to Jak and Daxter: The Precursor Legacy.It was followed by Jak 3 a year later. Due to Vin's previous relationship with the Underground, Torn sent Jak and Daxter on a mission to rescue him. However, Damas' son (later revealed to be Jak before he was sent to the past) escaped. This time, however, Daxter speaks up, and the leader - better known as Keira - … In animals with absolute polycythemia, fluid administration beyond replacement may be associated with cardiopulmonary failure as these animals are completely volume expanded. Author’s studies were supported in part by grants from the National Institutes of Health (OD010939) and the Winn Feline and other Foundations. It is revealed that Vin dumped his brain into the eco grid prior to his death, so he could exist as a "multi-layered hyper linking digi-memoc-bio-construct-super-clocked-mega-memory-construct"[2]—i.e. Jodidos huevos!! Language: English Location: United States Restricted Mode: Off Serum erythropoietin values, determined by a species-validated assay, may be elevated in cases of secondary polycythemia, but a normal to low erythropoietin level does not rule out secondary polycythemia. Vin is a scientist who sends Jak on several missions outside of Haven City. Although strictly speaking polycythemia implies a rise of all blood cell counts above normal, the occurrence of leukocytosis and thrombocytosis along with erythrocytosis is exceptionally rare in companion animals. Take your favorite fandoms with you and never miss a beat. Neurologic signs are the most common presenting complaints, but with the advent of more frequent health screens including complete blood cell counts, the erythrocytosis may be discovered earlier as an incidental finding. Polycythemic animals will not show clinical signs until the PCV reaches >60% with some of the highest PCVs exceeding 85%. Both are required, but you can do them in either order. This may be considered an appropriate response in which the erythron is responding normally to generalized tissue hypoxia or inappropriate in which the erythropoiesis is being stimulated by an aberrant production of erythropoietin or due to local renal hypoxia. Yon moun san w ale avè l e san l ale avè w. Yon moun ki gen yon bèl pèsonalite ak yon seri kalite ou apresye. Brutter voiced by Alan Blumenfeld and 5 others . What the users think. Welcome to Jak II HD!Originally released as Jak II: Renegade in 2003 on the Playstation 2, this HD re-release gives you the chance to join Jak and Daxter on their second adventure in the series, which is set in the city of New Haven far into the future from the previous game. Baron Praxis used the strip mine as some means to provide such eco to the Metal Heads by installing eco wells and leaving them open for the taking, under the pretense to the people that he would eventually pipe them into the eco gridfor the city. JAK 2 El Renegado - Cap.6 - Salvando a VIN! "So, our newest recruit saved you." Appropriate PCV rises are seen in high altitudes and with cardiopulmonary disease such as congenital heart defects with right to left shunts (ventricular septal defects, reversed PDA, Tetralogy of Fallot) and rarely chronic obstructive pulmonary diseases. Jak gets thrown into the future and is imprisoned and tortured with dark eco. Long-term follow up has not been reported in animals, although the author has observed persistent polycythemia for more than a decade in certain animals. Vin appears to be elderly given his gray hair and slightly aged skin, though his age is hard to tell due to his frenetic nature. He helped Jak and Daxter retrieve the artifact to unlock the doors at the KG war factory. He is deathly afraid of metal heads, constantly worried he is going to die, and in a near-constant state of panic. Furthermore, an appropriate secondary polycythemia has been documented in several breeds of dogs and domestic shorthair cats with hereditary methemoglobin reductase deficiency, which results in the erythrocytes’ inability to carry oxygen. Some clinicians readily equate absolute erythrocytosis with polycythemia vera (P. vera) without considering other differential diagnoses. Based upon blood volume and red cell mass, polycythemia can be divided into relative and absolute polycythemias, which represent completely different conditions, both requiring immediate but opposing therapeutic interventions. 2003's "Jak II" is a Naughty Dog release, and a sequel to their prior release "Jak and Daxter: The Precursor Saga." P. vera, therefore, results in the accumulation of morphologically normal red blood cells, and less commonly white cells and platelets, and their progenitor cells in the absence of a definable stimulus. Concept art, character artwork, and during Ja… Jak 2 El Renegado - Cap.6 Salvando... Need saving, Torn. this time, however, suggests that P. vera ) without considering other differential.... Can do them in either order II is a scientist who sends on. This when Jak says he is going to die, and promotional pictures next rightful to. Past ) escaped occur rarely compared to other forms of polycythemia intoxication can cause with... 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